Daniel LingwoodAssistant Professor of Medicine at The Ragon Institute of MGH, MIT and Harv
Dr. Lingwood’s training has been at the interface of B cell receptor (BCR) biology and membrane structure and function. His doctoral work at the Max Planck Institute for Molecular Biology and Genetics, helped to define the Lipid Raft property as a cell membrane subcompartmentalization principle and allosteric modulator of cell surface recognition processes. As a research fellow at the Vaccine Research Center at the NIH, Dr. Lingwood showed that the specific membrane orientation of the BCR enabled human germline-encoded antibody sequences to naturally engage conserved sites of viral vulnerability on influenza virus. As an Assistant Professor of Medicine at The Ragon Institute of MGH, MIT and Harvard, Dr. Lingwood has deployed transgenic mouse models in which human-like antibody diversity is compositionally controlled and mimicked, leading to the demonstration that such germline-encoded B cell targeting of microbial antigen is a widespread phenomenon, and can be harnessed to selectively ‘pathway-amplify’ broad spectrum antibodies engaging invariant microbial features.