Nicolas Bery, Ph.D.Senior Postdoctoral Scientist at Cancer Research Centre of Toulouse CRCT
I completed my MSc degrees in Biochemistry at the INSA Toulouse and in Cancer Research at the University of Toulouse, France. I received my Ph.D. in Cancer Biology from the University of Toulouse. My PhD focused on the characterisation of a novel synthetic library of nanobodies (NaLi-H1) and on the development of intracellular single domain antibodies targeting selectively the RAS-related small GTPase RHOB.
In April 2015, I joined Prof. Rabbitts' group at the University of Oxford. During my postdoctoral experience, I used iDAbs as tools to directly screen and characterise small molecules emulating the function of anti-LMO2 and anti-RAS iDAbs with the development of BRET-based biosensors. I also employed intracellular antibody mimetic domains (DARPins) to uncover, characterise and validate novel targetable interfaces on the difficult-to-target RAS/KRAS oncoproteins for the future development of small molecules but also to discover novel therapeutic strategies to target specifically KRAS via the degrader technology.