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Antibody Engineering & Therapeutics Europe
6 - 8 June, 2023
Postillon Hotel AmsterdamDigital Experience: All Sessions Live-streamed 6-8 June, 2023

Thom Sharp, PhD
Associate Professor at Leiden University Medical Center

Profile

Thom Sharp is an associate professor at the LUMC and head of the BioNanoPatterning group. At the LUMC, before starting the BioNanoPatterning lab, Thom’s research focussed on the use of electron cryo-tomography, combined with subtomogram averaging, to determine the structures of different macromolecular protein complexes of the innate immune system. Before moving to the Netherlands, Thom was a postdoc at the University of Oxford, UK, where he worked in the Division of Structural Biology (STRUBI) and the Department of Physics with Andrew Turberfield. Whilst there he designed and tested DNA-templated protein arrays as a tool for high-throughput protein structure determination using cryoTEM and single-particle analysis. Thom performed his PhD jointly between the groups of Dek Woolfson (Chemistry) and Paul Verkade (Biochemistry) at the University of Bristol, UK focussing on the utilisation of cryoEM to elucidate the superstructure of self-assembled peptide fibres, and the development of new in vivo probes for Correlative Light Electron Microscopy (CLEM).

Agenda Sessions

  • In situ Imaging of IgG3-mediated Complement Activation Using Cryo-electron Tomography Reveals Novel Structural Insights into Immune Defense

    08:50

Speakers at this event