Andrew Ward, PhDProfessor, Department of Integrative Structural and Computational Biology at The Scripps Research Institute
I received my Ph.D. and postdoctoral training at the Scripps Research Institute and continued on as an independent investigator in 2010. My laboratory works on a variety of biological problems in areas including structural virology, structural immunology, and membrane protein biology. We employ many structural and biophysical techniques to provide molecular details of biological systems at resolutions ranging from near atomic to ~50 Å. This broad range allows us to explore various facets of the biology of cellular and viral complexes, particularly those associated with the membrane, and including HIV-1, hepatitis C, Ebola, coronaviruses, influenza and others. We have developed a robust electron microscopy pipeline to provide rapid structural characterization of viral envelope glycoproteins in complex with monoclonal antibodies (mAb) at both low (15-20 Å) and high resolutions (~3-10 Å). We also developed a new technique known as electron microscopy polyclonal epitope mapping (EMPEM) to observe all of the antibody specificities to viral antigens within a single experiment, thereby circumventing a major bottleneck in analysis of immune responses to experimental vaccines.