Coauthors:
Ji Young L. Anderson[1]; Kenion H. Blakeman[1]; Kerin E. Gregory [1]
Affiliations:
[1] 908 Devices Inc., 645 Summer St., Boston, MA 02210

Abstract:
There is a need for advanced process analytical technologies that can monitor essential bioreactor nutrients and cellular metabolites alongside bioreactors in process development labs. Shown here is a new benchtop analyzer called the REBEL. The REBEL enables wide (32 analytes) and rapid analysis of cell media with just ten microliters of sample to expedite process development decisions. The REBEL can run samples with only filtration and dilution, which is much simpler than the lengthy and costly derivatization schemes and analysis times required of comparable approaches. The potential benefits of putting the REBEL at the point-of-need include reduced reliance on the "centralized laboratory" model, decreased capital and facility costs, more rapid (near real-time) analytics feedback, and improved product quality and titer. The low sample volume requirement for this analyzer allows for cell media optimization to occur earlier in the process development stage (e.g., at the microtiter plate and microbioreactor scale) where total bioreactor volumes are small, and the scientist desires to run assays every day during the process. This presentation will highlight the platform's general capabilities and several applications of fresh and spent media analysis.
Take-Home Message:
Presented here is a new automated benchtop analyzer for targeted cell media analysis. The data provided by the system may accelerate process development analytics by days to weeks over traditional core lab or 3rd-party test practices.

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