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Introduction to Antibody Engineering Training Course (1-3 June 2022)
1-3 June, 2022
Digital Training Course3:00PM-5:30PM BST // 10:00AM-12:30PM EDT

Why attend Introduction to Antibody Engineering?

Today’s wealth of knowledge of protein structures will be reviewed along with the genetics of diversity generation of antibodies, to give insights into the best strategies for improving protein function. There is particular emphasis on the choice of a functional assay to monitor effectively the changes in a desired property, and the use of functional enrichment steps where a library approach is employed. Not only is amino acid sequence amenable to may also be engineered. The course will focus on the engineering and enhancement of antibodies and antibody-like scaffolds. Examples will include work on antibody by diverse approaches and the adaptation to generate Chimeric Antibody Receptor (CAR) constructs will be discussed. Expression platforms for producing antibodies for testing and for manufacture will also be covered. A background in biochemistry and molecular biology is useful, as the course is designed to progress rapidly from simple to advanced concepts.

FORMAT

The course will be 2.5 hours each day. In addition to the content below there will be (1) break per day as well as time for Q&A and group discussion.

DATE & TIME

1-3 June, 2022
3:00PM - 5:30PM British Summer Time (BST) // 10:00AM - 12:30PM Eastern Standard Time (EST) // 07:00AM - 09:30AM Pacific Standard Time (PST)

Topics Include

  • Functions amenable to engineering: affinity, specificity, stability, solubility, immunogenicity
  • The measure of success: functional assays
  • Engineering by design
  • Engineering by random mutation
  • Designed libraries
  • Display technologies
  • Improving manufacturing by protein engineering methods
  • Glycosylation engineering – function and homogeneity
  • Other protein modifications
  • Immunogenicity engineering
  • Bispecific antibodies
  • Antibody-drug conjugates (ADCs)
  • CAR-T strategies
  • Expression of antibodies and fragments for discovery and testing
  • Manufacturing platforms for antibodies and fragments