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May 9-12, 2022Hynes Convention Center, Boston

Punit Seth, PhD
Vice President, Medicinal Chemistry at Ionis Pharmaceuticals


Dr. Punit P. Seth heads medicinal chemistry and targeted delivery at Ionis Pharmaceuticals. Dr. Seth is co-inventor of Ionis’ Gen 2.5 platform which employs high affinity nucleoside modifications to enhance the affinity, stability and potency of ASOs in the liver and in extra-hepatic tissues. He is also the co-inventor of Ionis’ LICA (ligand conjugated antisense oligonucleotides) platform which enhances ASO potency by targeted delivery to cells and tissues of interest. He has extensive experience with using medicinal chemistry strategies to modulate the activity, pharmacokinetic and toxicological properties of oligonucleotide drugs. Dr. Seth is listed as co-author/co-inventor on close to 200 peer-reviewed publications, issued patents and patent applications. He has a Ph.D in organic chemistry from The Ohio State University.

Agenda Sessions

  • ROOM 205A: Chairman’s Remarks

  • ROOM 205A: Redefining the Chemical Space for Antisense Therapeutics

  • ROOM 204AB: Redefining the chemical space for nucleic acid therapeutics

  • FEATURED MINI-SYMPOSIUM AND LIVE PANEL DISCUSSION WITH LIVE Q&A: Targeted Delivery of Oligonucleotides: Tissue-Specific Challenges and Novel Conjugation Strategies