Randall Mrsny, Ph.D.Professor of Epithelial Biology at University of Bath
Randall Mrsny obtained a BS degree in Biochemistry and Biophysics and a PhD degree in Human Anatomy and Cell Biology from the University of California at Davis undergraduate and medical school campuses, respectively. His PhD thesis on mammalian sperm capacitation events helped identify the culture system that allowed the first human in vitro fertilization to occur. As an NIH post-doctoral fellow at the Institute of Molecular Biology located in the University of Oregon, his work in membrane biophysics studied lipid-protein interactions that helped define the lipid anulus model of cell membrane organization. Prior to taking Professors’ post in Cardiff University and now the University of Bath, Randy led research groups in two companies: ALZA and Genentech where he examined a variety of drug delivery strategies to optimize the clinical utilization of new protein and peptide therapeutics. Following his departure from Genentech, he started two new venture capital-funded biotech companies, one of which is now poised to enter its first product into Phase II clinical testing. Randy has been elected president of the Controlled Release Society, elected to its College of fellow, and received the Founder’s Award from this same organization. He has been recognized in the International Medicine Maker 100 power list, elected co-chair of the Gordon Conference on Drug Carriers in Biology and Medicine, and organized international meetings. He currently serves as a reviewer or advisor for multiple international agencies and companies.
The current research interest of the Mrsny Laboratory focuses on a variety of aspects of epithelial cell structure/function in health and disease. This work is supported through grants from governmental agencies and private foundations as well as through collaborative partnership with pharmaceutical companies.
- Identification of molecules secreted by intestinal and airway epithelial cells which can control neutrophil and eosinophil transmigration
- Identification of molecules that allow epithelial cells regulation to lymphocyte activation
- Examine the role played by tight junction elements in controlling epithelial cells oncogenesis
- Examine endogenous mechanisms that dynamically control tight junction opening and closing for drug delivery
- Examine epithelial transcytosis mechanisms used by bacterial toxins for the delivery of biotherapeutics such as proteins, peptides, and siRNA.”