Peri-Nuc Labs is a Houston based company developing novel technologies for cancer research and diagnostics. Our most recent technology of extracting malignant cells from frozen tumors is ready for market. Patent US 20,210,348,993 A1. Malignant cells extracted from frozen tumors by our technology are authentic and free of blood and other stromal elements. Tumor cells are intact with preserved cell surface antigens that allows cell sorting and isolation of cell population. We will provide native tumor cells for researchers in academia and private industry for research and hospitals for diagnostics. We are also establishing the world’s first authentic human tumor cell banks from frozen tumors. We were able to isolate elusive cytomatrix that was first observed by K. Porter five decades ago (iScience, 2023, PMID:36824274). Our comprehensive research involving current high-throughput methods shows the importance of the cytomatrix for cancer development and drug resistance. We believe our findings will be a significant breakthrough in cancer research after publication. The paper is ready for submission. Lastly, we have patent issued in 2021 for a technology to screen chemical compounds, potentially suppressing the cytomatrix. Patent US 11,428,693 B2. Our high-throughput method screens about 5000-10,000 compounds, including a selection of potential anti-cancer drugs that can increase the efficiency of anti-cancer therapy.