Yiming Yin, Ph.D.

Postdoctoral Research Fellow at Boston Children's Hospital

Speaker

Dr. Yiming Yin received her undergraduate degree from Tsinghua University and her Ph.D. from Scripps Research Institute, where she developed a novel approach for in vitro mammalian display of antibodies and biologics. Her post-doctoral studies in the laboratory of Michael Farzan at Boston Children’s Hospital and Harvard Medical School have focused on engineering and in vivo development of primary B cells. This work led to the development of a process for scarlessly replacing mouse and macaque antibody heavy- and light chain genes with those expressing human antibodies. This process uniquely preserves the ability of these cells to affinity mature in vivo. She is now pursuing the clinical and scientific uses of in vivo affinity maturation. These include the development of broader, more potent, and more bioavailable antibodies, generation of new vaccine models, scientific study of B cell maturation, and exploration of the clinical uses of engineered B cells, including those against HIV-1.