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Antibody Engineering

Using next gen protein therapeutics over traditional mAbs - WHITEPAPER

Increasingly next generation proteins are being used over traditional monoclonal antibodies. This exclusive whitepaper explores the different approaches, competitive advantages and challenges of these next gen therapeutics.

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According to BIS Research and Research and Markets the worldwide biologics drug discovery market is predicted to increase from USD $8.1 billion in 2015 to USD $22.7 billion by 2025. The biologics discovery growth rate is predicted to be faster than in the dominant small molecule discovery sector. Monoclonal antibodies are expected to make up just under half of the biologics discovery market in 2025. Engineered or recombinant proteins such as next generation protein therapeutics are expected to contribute 3 billion to the market in 2025.

The dominance of monoclonal antibodies (mAbs) are due to several factors including their efficacy brought about by their high specificity allowing selective targeting; long half-life compared to small molecules due to the presence of the Fc region that allows the antibodies to engage the FcRn mediated salvage; and the ability to activate immunemediated effector functions, e.g. antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), via the interaction of Fc portion with Fc-gamma receptors. Promoting their adoption, Mabs have proven useful in the rapidly expanding immune-oncology field which has led to a proliferation of antibody products through “copy-cat” development. Mabs, however have important disadvantages such as cost of goods that next generation protein therapeutics do not suffer from.

Next generation protein therapeutics can be considered antibody mimetics as each protein therapeutic is composed of a constant region, which stabilizes the overall protein folding, and variable regions that facilitate its target binding. The specificities of these next generation proteins variable regions can be directed in vitro, contrasting antibodies and antibody fragments which require the immunisation of animals to generate.

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