This webinar detailed the importance of choosing a correctly sized/configured oligosynthesizer for your scale-up process (‘synth core’), the criticality of leaning on automation to define/edit the synthesis methods (molar EQs) and considerations for optimizing coupling efficiency to increase productivity.
Oligonucleotide producers looking to scale-up from laboratory to commercial manufacturing processes need to ensure that they choose a correctly sized and configured oligosynthesizer because otherwise their process will be inefficient, leading to unnecessary waste and reduced productivity.
Synthesis problems can stem from a lack of robust automation software used to build the methods, poorly defined parameters and a complex, difficult-to-navigate user interface.
Productivity can be severely hampered by amidite coupling inefficiency, which must be properly monitored and controlled throughout the synthesis process.
This webcast detailed how to choose the correctly sized oligosythesizer for your scale-up process, the criticality of leaning on automation to define/edit the synthesis methods and considerations for optimizing coupling efficiency to increase productivity.
Key Takeaways:
- Using the right equipment for your specific manufacturing process can substantially increase product safety, process efficiency and overall productivity.
- Manufacturing oligonucleotides at a commercial level can present different challenges than the lab environment – collaboration with experienced partners is a key to success
This webcast features Cory Hinz, Engineering Manager at Asahi Kasei Bioprocess America, George Flores, Technical Solutions Manager at Asahi Kasei Bioprocess America, and Stefan Hyde, Automation Manager at Asahi Kasei Bioprocess America.