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Bioprocessing & Manufacturing

Next Gen protein drug challenges and the latest technologies to overcome them - WHITEPAPER


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There are a number of challenges facing protein-based therapeutics, including fast degradation in serum, quick elimination due to enzymatic degradation, and parenteral administration meaning they require multiple injections.

However, innovative new technologies and methods are being used to overcome them. This whitepaper looks at the challenges and how they are being tackled, including:

  • XTEN, a revolutionary PEG mimetic

  • Binding albumin for a longer therapeutic window

  • Adepts of less toxic treatments

  • Metal-organic hybrid polymers to deliver protein drugs

  • Disrupting PPIs

  • Machine-learning bioinformatic tools to support protein drug design

  • Cytokine interaction and release

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