Rapid characterization of oligonucleotides using microfluidic capillary electrophoresis

This work presents a CE-MS analysis of oligos by ZipChip coupled to a Thermo Scientific QExactive HF mass spectrometer. This positive ESI mode method utilizes a MS-friendly background electrolyte that eliminates the use of ion paring agents such as hexafluoro isopropanol or alkyl amines. This ensures fast switching time between methods, and no downtime associated with instrument decontamination. The analysis times are short (typically < 5) with minimum method development required.

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