Early Registration Deadline:
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Day One (13th May 2025) - CET/CEST (Cent Europe Summer, GMT+2)
Can we create a platform approach to cell engineering?
- Shan-Hua Chung - Senior Scientist, People Lead Cell Technologies, Roche
- David Öling - Director, Molecular Biology and Recombinant Protein Production, AstraZeneca
Piggybac, Leap-In, Sleeping Beauty – case studies on how these compare to random integration and have advantages been achieved?
Comparison of targeted integration (TI) and PiggyBac integration
Impact of copy number and integration sites on productivity and stability
- Moritz Schmidt - Head of Laboratory Molecular Biology, Boehringer Ingelheim
When generating CHO based production clones, a significant amount of time is spent selecting clones and creating an optimal bioprocess. Our research indicates that these steps can be entirely skipped simply by employing a recombinase-based targeted gene integration strategy. The clones generated this way, all behave similarly in bioprocess suggesting that a one-time pre-optimized bioprocess is all you need.
- Lasse Ebdrup Pedersen - Associate Professor, The Technical University of Denmark
- Jose Miguel Escandell Planells - Principal Scientist, iBET - Instituto de Biologia Experimental e Tecnológica
2 Round Tables each covering Systems or Engineering Biology. Each will be led by an expert. The expert will kick off and guide the discussion which will last for 30 minutes. At the end of the 30 minutes the leader will report their main conclusions to the room for a maximum of 15 minutes.
Roundtable Discussions
What is systems biology, and how does it differ from traditional approaches in cell line development?
How can integrating genomics, transcriptomics, proteomics, and metabolomics data enhance cell line development?
What role does systems biology play in enhancing the stability and productivity of cell lines?
What are the current challenges in applying systems biology to cell line development, and what are the future directions for this field?
How can collaboration between biologists, engineers, data scientists, and clinicians accelerate the development of more predictable and enhanced therapeutics?
Engineering “Synthetic” Biology in Cell Line Development
What is synthetic biology, and how is it being applied to cell line development?
How can synthetic biology be used to reprogram metabolic pathways to improve cell line productivity?
What are the key advantages of using cell-free expression systems in synthetic biology for cell line development?
What are the future prospects for synthetic biology in cell line development, and what innovations are on the horizon?