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Webinar: New Findings in The Amide Bond Forming Conditions Typically Used in The Peptide Manufacturing Industry (June 2 at 10am EDT)
Since the invention of the solid phase peptide synthesis (SPPS) by Merrifield more than 5 decades ago, the technology to make peptides has evolved dramatically. The coupling reaction, so essential to making an amide bond, traditionally had the sole objectives of forming the amide bond effectively, i.e. going to completion, while limiting racemization. Lately, a lot of attention has been given to additional aspects of the coupling reaction in terms of process understanding, greening - hereunder EHS perspectives - as well as control of side reactions. Using in-house examples, this presentation will picture the new insights of the complex coupling reaction.