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Antibody Engineering & Therapeutics Europe
4 - 6 June, 2024
Excel London Platinum Suite

Leo James, PhD
MRC Programme Leader at MRC Laboratory of Molecular Biology


Leo trained with Prof. Dan Tawfik and Sir Greg Winter before establishing his own lab at the MRC Laboratory of Molecular Biology in Cambridge in 2007. Significant work includes the discovery of the cytosolic antibody receptor TRIM21 and dissection of how it prevents infection by intercepting viruses, bacteria and pathogenic proteins inside the cell and targeting them for rapid degradation. This work also led to the development of ‘TrimAway’, a technique which exploits TRIM21 for the rapid and specific degradation of cellular proteins.

Agenda Sessions

  • Targeted Degradation of Proteins and Pathogens by the Cytosolic Antibody Receptor TRIM21