Leo James, PhD

MRC Programme Leader at MRC Laboratory of Molecular Biology

Speaker

Leo trained with Prof. Dan Tawfik and Sir Greg Winter before establishing his own lab at the MRC Laboratory of Molecular Biology in Cambridge in 2007. Significant work includes the discovery of the cytosolic antibody receptor TRIM21 and dissection of how it prevents infection by intercepting viruses, bacteria and pathogenic proteins inside the cell and targeting them for rapid degradation. This work also led to the development of ‘TrimAway’, a technique which exploits TRIM21 for the rapid and specific degradation of cellular proteins.