Matwings Technology is dedicated to move beyond directed evolution methods to design and engineer functionally optimized proteins with proprietary AI models and ultra-large curated dataset with in house functional labels.

Here, we will present our proprietary oral uricase with superior stability in simulated intestinal fluid (SIF). This preclinical stage candidate can lower the serum uric acid by more than 50% in UOX mouse model with much less kidney injuries compared to allopurinol treatment.