Cell Culture & Upstream Processing Track

The upstream processing field is under pressure to boost productivity and reduce footprint. Intensified processes - such as high-density cultures, perfusion or hybrid fed-batch modes - are becoming pivotal to driving higher titers and reducing cost of goods. Explore novel CHO cell line engineering and hybrid fed-batch approaches that rival traditional perfusion systems in this track.

Optimising the upstream cell culture environment - media composition, feed strategy, amino-acid uptake, metabolic pathways - remains a major lever for improving yield and maintaining product quality. Learn how new metabolic profiling and seed-vessel strategies are redefining process performance and product quality by joining sessions such as “Implementation of a perfusion seed vessel to increase cell mass as well as optimize feed composition and strategy”.

As processes move from bench to commercial scale, ensuring robustness, reproducibility and control becomes essential. Integrating real-time monitoring, digital twins, PAT tools and AI analytics supports predictive scale-up and process transfer. See how biocapacitance probes, digital twins, and machine learning models are empowering adaptive control with sessions such as “Adaptive Process Control Using Biocapacitance Probes in Mammalian Fed-Batch Cell Culture for Improved Process Robustness from Bench-top to Pilot Scale".

Upstream performance is often limited by raw material variability and supply-chain disruptions. Ensuring consistency of media components, feedstocks and reagents is increasingly viewed as a strategic risk. Learn how upstream teams are qualifying suppliers, monitoring variability, and implementing quality frameworks that safeguard culture performance with sessions such as “Standardizing Raw Material Characterization for Regulatory Acceptance".