Moving from Monitoring to Adaptive Control in Upstream Processing
Bioprocess monitoring has come a long way, but the next frontier is not simply about collecting more data, it’s about acting on it in real time. Modern manufacturing demands systems that are not only informative but adaptive, enabling teams to respond proactively to changes before they impact yield or quality.
Cindy Chelius brings deep expertise in this area, exploring how adaptive process control strategies can revolutionize variability management and operational predictability. At Bristol Myers Squibb, she focuses on translating advanced sensing technologies, including biocapacitance probe integration in mammalian fed-batch cell culture, into actionable, real-time process control strategies. Her work bridges cutting-edge instrumentation with practical, data-driven decision-making, enabling more predictable and efficient upstream operations.
At BPI West 2026, Cindy’s session will take a close look at how integrating adaptive monitoring approaches can transform bioprocess development and scale-up. Attendees will gain valuable insights into:
Implementing real-time probes to enhance culture feedback – capturing critical process parameters to respond dynamically to changing conditions.
Using dynamic control strategies to boost productivity – optimizing feed rates, environmental conditions, and process interventions in real time.
Reducing scale-up risk through data-driven adjustments – anticipating variability before it affects final output, ensuring smoother translation from lab to manufacturing.
As biologics programs push toward higher titers, tighter timelines, and increasingly complex molecules, reactive adjustments are no longer sufficient. Adaptive control systems represent a fundamental shift from traditional monitoring to proactive process optimization — a theme at the heart of this year’s upstream track. Cindy’s session offers attendees a clear roadmap for leveraging real-time data to make smarter, faster, and more reliable bioprocessing decisions.
Don’t miss this opportunity to explore how next-generation sensing and adaptive control can elevate upstream performance, reduce risk, and empower your teams to stay ahead in an increasingly competitive landscape.