Breaking Through Downstream Bottlenecks

As upstream productivity continues to climb, downstream processing must evolve to keep pace. In intensified bioprocessing, filtration and purification steps often become the critical bottlenecks, limiting overall throughput and challenging both timelines and costs. Overcoming these constraints requires innovative approaches that balance efficiency, yield, and product quality.

David Scherr brings deep applied downstream expertise from AstraZeneca, where he focuses on advancing strategies to enhance depth filtration performance. His work emphasizes practical, data-driven solutions that improve operational efficiency without compromising product integrity. In his featured session, David will present a compelling case study demonstrating how cycling operations during integrated dynamic bioprocessing can significantly increase filter capacity and process throughput.

Attendees will gain actionable insights into:

• Methods to improve depth filter utilization – optimizing operations to get the most from existing equipment.

• Strategies for balancing yield and product quality – ensuring process efficiency doesn’t come at the expense of critical quality attributes.

• Practical adjustments for higher upstream titers – adapting downstream processes to handle intensified feeds without compromising performance.

For downstream scientists facing capacity constraints and cost pressures, this session delivers both conceptual innovation and operational detail. It tackles one of the most pressing scalability challenges in biologics manufacturing, offering strategies that can be implemented immediately to support faster, more robust production.

Don’t miss this opportunity to explore how thoughtful downstream design and adaptive operations can unlock the full potential of your intensified bioprocessing workflows.