Downstream Processing Track
As upstream titers rise and modalities become more complex, efficient, robust and scalable downstream processes are critical. Global recovery and purification experts will share cutting-edge strategies in chromatography, filtration, process digitalization, and sustainable purification.
Purifying with Purpose – Smarter, Faster, and Built to Scale - Key Topics in Downstream Processing:
Intensified & Continuous Purification Systems
Strategies like multi-column chromatography and modular downstream trains reduce bottlenecks, footprint, and cost-of-goods. Explore how downstream teams are adopting continuous and connected chromatography platforms to match the productivity gains from upstream intensification.
Next-Generation Purification for Complex Modalities
Next-generation biologics require tailored capture strategies, from novel affinity ligands to modular chromatography approaches. These tools improve throughput and adaptability for multi-specifics, viral vectors, and LNPs. Learn how cutting-edge purification strategies are enabling robust, scalable processing for today’s diverse biologics portfolio.
Digitalisation, Process Analytics & Real‑Time Release in Purification
Digital transformation is not just for upstream innovation - downstream processing can benefit enormously from real‑time monitoring, digital twins, PAT (process analytical technology), and data‑driven control. Join sessions like “Implementing Digital Twins to Support Real‑Time Release in DSP” which will reveal how these technologies help to ensure consistency, reduce validation burdens and accelerate commercialization.
Sustainable, Robust Downstream Supply Chains & Materials
Downstream processing often hinges on materials - resins, membranes, buffers, single‑use assemblies - and supply‑chain robustness is becoming a strategic concern with operations often under pressure to reduce footprint, improve resin utilization, and lower cost-of-goods. Join sessions like “Product Sustainability Strategy – Addressing Environmental Impact Across the Product Lifecycle” which will look at sustainability and supply‑chain continuity in DSP.
Downstream Processing Speaker Snapshot
FAQs
What is the focus of the Downstream Processing track at BPI West?
The Downstream Processing track at BPI West focuses on innovations and strategies to optimize purification, recovery, and scalability in biopharmaceutical manufacturing. It covers topics such as continuous processing, chromatography advancements, and process intensification.
What are the key industry trends in downstream processing discussed at BPI West?
Key trends include:
- The adoption of continuous downstream processing for efficiency and scalability.
- Advances in chromatography technologies, including multi-column and membrane-based systems.
- Integration of AI and machine learning for process optimization.
- Strategies for reducing costs and improving sustainability in purification processes.
How does continuous processing impact downstream biopharmaceutical workflows?
Continuous processing is revolutionizing downstream workflows by enabling higher throughput, reducing bottlenecks, and improving product consistency. Sessions at BPI West explore real-world applications and challenges in implementing continuous processing systems.
What challenges in downstream processing are addressed at BPI West?
The agenda addresses challenges such as:
- Managing variability in raw materials and feed streams.
- Scaling purification processes for commercial production.
- Reducing costs while maintaining high product quality.
- Navigating regulatory requirements for downstream operations.
What technologies are highlighted in the Downstream Processing agenda?
Highlighted technologies include:
- Multi-column chromatography systems for enhanced efficiency.
- Membrane-based purification methods.
- AI-driven tools for process monitoring and optimization.
- Single-use technologies for flexible manufacturing.
How does the Downstream Processing track address regulatory compliance?
The track delves into the complexities of regulatory compliance specific to downstream operations, including:
- Strategies for ensuring consistent product quality during purification and recovery.
- Approaches to process validation and meeting global regulatory standards.
- Insights into managing regulatory challenges for emerging modalities like cell and gene therapies.
Are there case studies presented in the Downstream Processing track?
Yes, our agenda includes case studies showcasing successful downstream processing strategies, highlighting innovative approaches and lessons learned.
What are the benefits of attending the Downstream Processing track?
Attendees will gain:
- A deeper understanding of how to implement continuous processing and intensification strategies.
- Access to expert-led discussions on overcoming bottlenecks in purification and recovery.
- Opportunities to explore cutting-edge technologies like multi-column chromatography and membrane systems.
- Insights into cost-saving measures and sustainable practices in downstream workflows.
Where can I find news and resources for Downstream Processing?
Browse our partner media site, BioProcess International, which includes news, webinars and resources within downstream processing and the wider bioprocessing industry.