Main Conference Day 3 (30th April 2026) - CET/CEST (Cent Europe Summer, GMT+2)
Accurate prediction of final clone performance and stability with AI/ML models
Utilising AI/ML for:
Reduction in number of clones required for downstream
Improving identification of top-tier producers
Overcoming data infrastructure and validation challenges for successful implementation into a GMP workflow
- Adam Brown, Ph.D. - Professor of Biopharmaceutical Engineering, University of Sheffield
- Mario Gimona - Head of R&D 'Nanovesicular Therapeutics', Ludwig Boltzmann Institute of Nanovesicular Precision Medicine & Paracelsus Medical University, Austria
- Giovanni Ganendra - Upstream Process Science Senior Scientist, UCB Pharma
- Dong-Qiang Lin - Professor, Zhejiang University
- Maria del Carme Pons Royo - Postdoctoral Associate, Massachusetts Institute of Technology (MIT)
ADDomer is an emerging self-assembling protein nanoparticle with strong potential for vaccine and therapeutic applications, including emerging infectious diseases, oncology, and neglected tropical diseases such as snakebite venom. However, manufacturing strategies for these complex nanoparticles remain constrained by multi-step batch downstream processes that limit efficiency and scalability.
This work addresses the challenges of developing an integrated and continuous downstream platform for ADDomer. Following expression in insect cells, a streamlined clarification and membrane-based capture strategy was implemented, and continuous chromatography for capture is currently under development. The study highlights key considerations for improving manufacturability and accelerating the scalable industrial implementation of next-generation nanoparticle vaccines.
- Salomé Mateus Forte Neto - PhD Student, iBET
- Lior Shaltiel - CEO, NurExone Biologic
Have a Solution for This Challenge?
This session is your platform to demonstrate leadership and technical expertise. Present your data, case studies, and innovative solutions to a targeted audience of senior scientists and engineers looking to solve hurdles in their production processes.
To learn more about sponsoring this session, contact us at Partners@informaconnectls.com
- Christian Witz - CEO, SimVantage GmbH
- Jane Worthington - Global Change Facilitator/Project Manager, BioPhorum
- Maria Boulieri - Lead Privacy Counsel, Europe, Chiesi Group
- David Pfister - Head of Research & Development, Ypso-Facto
- Cornelia Walther - Principal Scientist Downstream Development | Development Operations Vienna, Boehringer Ingelheim RCV GmbH & Co KG
- Paula Meleady - Associate Professor, School of Biotechnology, Dublin City University
- Zeynep Betts, PhD - Postdoctoral Research Associate, University of Manchester
- Sinead Dullaghan - Sr. Principal Scientist TSMS, Eli Lilly
- Nasrin Salehi - Senior Principal Scientist, Pfizer Inc.
- Tiffany Rau, PhD - Adjunct Professor Biochemistry and Cell Biology, University College Cork, Ireland
- Romain Nootens - Senior Process Engineer, UCB Pharma S.A.
- Manel Juan - Head of the Immunology Department, Hospital Clínic de Barcelona, Spain
- Manel Juan - Head of the Immunology Department, Hospital Clínic de Barcelona, Spain
- Tiffany Rau, PhD - Adjunct Professor Biochemistry and Cell Biology, University College Cork, Ireland
- Manuel Carrondo - Vice President, Instituto de Biologia Experimental e Tecnológica (iBET), Portugal
- Moritz von Stosch - Co Founding Partner, HINA Bioventures
Have a Solution for This Challenge?
This session is your platform to demonstrate leadership and technical expertise. Present your data, case studies, and innovative solutions to a targeted audience of senior scientists and engineers looking to solve hurdles in their production processes.
To learn more about sponsoring this session, contact us at Partners@informaconnectls.com
- Maxime Bergman - Senior Scientist Process II - Global Process Development, TDS, Drug Product Development & Delivery, Johnson & Johnson Innovative Medicine
- Marius Müller - Scientific Senior Manager - TDS Biologics AD, Johnson & Johnson Innovative Medicine
- Craig Walsh - Experienced Scientist MST - Clinical Manufacturing & Technology, Johnson & Johnson Innovative Medicine
- Christian Witz - CEO, SimVantage GmbH
Have a Solution for This Challenge?
This session is your platform to demonstrate leadership and technical expertise. Present your data, case studies, and innovative solutions to a targeted audience of senior scientists and engineers looking to solve hurdles in their production processes.
To learn more about sponsoring this session, contact us at Partners@informaconnectls.com
- Katharina Bruno-Thakur - Principal Scientist, F. Hoffmann-La Roche
Pinpointing the bottlenecks: do the biggest barriers to productivity come from cell biology, media formulation, bioreactor hardware, or process control?
Will AI and synthetic biology drive progress to design ‘super-producer’ cell lines in silico?
Is a diverse range of hosts needed for new modalities, or will a single, universal platform (e.g. advanced CHO cell) dominate?
Unlocking the next order-of-magnitude increase in productivity: what breakthroughs are needed?
- Patrick Harnedy - Senior Principal Engineer, Eli Lilly
- Gearóid Duane - Senior Principal Scientist, Bristol Myers Squibb, Cruiserath Biologics
- Eugenio Macchiarulo, Ph.D. - Director Research & Development, Lonza
- Katharina Bruno-Thakur - Principal Scientist, F. Hoffmann-La Roche
Pinpointing the bottlenecks: do the biggest barriers to productivity come from cell biology, media formulation, bioreactor hardware, or process control?
Will AI and synthetic biology drive progress to design ‘super-producer’ cell lines in silico?
Is a diverse range of hosts needed for new modalities, or will a single, universal platform (e.g. advanced CHO cell) dominate?
Unlocking the next order-of-magnitude increase in productivity: what breakthroughs are needed?
- Patrick Harnedy - Senior Principal Engineer, Eli Lilly
- Gearóid Duane - Senior Principal Scientist, Bristol Myers Squibb, Cruiserath Biologics
- Eugenio Macchiarulo, Ph.D. - Director Research & Development, Lonza
Approaching change on a large scale
Planning for phased implementation of sustainability practices
Seamless integration into existing workflows
Validation of new processes, technologies, etc.
Measurable impacts on carbon footprint
- Ana Cecilia Afonso Roque - Professor in Bioengineering, NOVA University of Lisbon
- Matthias Müllner - CEO, bespark*bio
- Mark Duerkop - Chief Executive Officer, Novasign, Austria
Identifying key cost drivers:
Raw Materials
QC
Labour
Etc.
How can targeted automation deliver efficiency?
Data-driven strategies to deliver significant cost reductions and open accessibility for patients worldwide
- Kat Kozyrytska - Founder, Cell Therapy Manufacturability Program
- Andrew Harmon - Manager, Sia Partners
- Dénes Zalai - Director Technology, Eleva Biologics
- Matthias Müllner - CEO, bespark*bio
- Mark Duerkop - Chief Executive Officer, Novasign, Austria
Identifying key cost drivers:
Raw Materials
QC
Labour
Etc.
How can targeted automation deliver efficiency?
Data-driven strategies to deliver significant cost reductions and open accessibility for patients worldwide
- Kat Kozyrytska - Founder, Cell Therapy Manufacturability Program
- Andrew Harmon - Manager, Sia Partners
- Dénes Zalai - Director Technology, Eleva Biologics