Introduction to Speaker and Workshop

• Welcome words
• Speaker introduction
• Content of the Workshop
• What is a conjugate?

Introduction to Therapeutic Oligonucleotide Conjugates I

• Different types of oligonucleotides and their mode of action.
• Why do we need Oligonucleotide conjugates?
• Do we always need Oligonucleotide conjugates?
• Clinical status of Oligonucleotide conjugates

Introduction to Therapeutic Oligonucleotide Conjugates II

• Disease Areas of interest
• Ligand opportunities
• Lipid, Antibody, GalNAc siRNA conjugates
• Lipid, Antibody, GalNac ASO conjugates
• Peptide ASO, SSO conjugates
• Antibody SSO conjugates
• Two choices in Oligonucleotide conjugate synthesis

Oligonucleotide Conjugate Synthesis

• Solid phase synthesis of conjugates
• Solution phase synthesis of conjugates

Short Recapture of Day 1

Oligonucleotide Conjugate Synthesis

• Case examples of Solid phase oligonucleotide conjugate synthesis
• Case examples of Solution phase oligonucleotide conjugate synthesis

In depth Oligonucleotide Conjugate Synthesis

• Conjugation positions per specific oligonucleotide type
• Building block opportunities
• Conjugation reactions
• Linker opportunities

Biological Impact of Oligonucleotide Conjugates

• Short recapture of Day 1 and 2
• The biological impact of ligand conjugation
• Selecting your conjugation strategy
• To release or not to release your ligand

Case Examples

• Case examples of biological impact as a result of conjugation control
  

How to Setup Your Own Conjugation Chemistry