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Oligonucleotide Conjugate Strategies
April 25-27, 2023
11:00AM-1:30 ESTOnline Training Course
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Below is What Will Be Covered:

The course will be 2.5 each day. In addition to the content below there will be (1) break per day as well as time for Q&A and group discussion.

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Day 1 - Tuesday, April 25

Introduction to Speaker and Workshop

  • Welcome words
  • Speaker introduction
  • Content of the Workshop
  • What is a conjugate?

Introduction to Therapeutic Oligonucleotide Conjugates I

  • Different types of oligonucleotides and their mode of action.
  • Why do we need Oligonucleotide conjugates?
  • Do we always need Oligonucleotide conjugates?
  • Clinical status of Oligonucleotide conjugates

Introduction to Therapeutic Oligonucleotide Conjugates II

  • Disease Areas of interest
  • Ligand opportunities
  • Lipid, Antibody, GalNAc siRNA conjugates
  • Lipid, Antibody, GalNac ASO conjugates
  • Peptide ASO, SSO conjugates
  • Antibody SSO conjugates
  • Two choices in Oligonucleotide conjugate synthesis

Oligonucleotide Conjugate Synthesis

  • Solid phase synthesis of conjugates
  • Solution phase synthesis of conjugates