June 8-10 Training Course Schedule
12:00pm - 12:30pm EST / 9:00am - 11:30am PCT / 5:00pm - 7:30pm GMT / 6:00pm - 8:30pm CET
This course will also be available on-demand for anyone with a time conflict.
Day 1 - Tuesday, June 8
(12:00pm - 12:30pm EST)
Introduction to Speaker and Workshop
- Welcome words
- Speaker introduction
- Content of the Workshop
- What is a conjugate?
(12:30pm - 1:00pm EST)
Introduction to Therapeutic Oligonucleotide Conjugates I
- Different types of oligonucleotides and their mode of action.
- Why do we need Oligonucleotide conjugates?
- Do we always need Oligonucleotide conjugates?
- Clinical status of Oligonucleotide conjugates
(1:00pm - 1:15pm EST)
Break
(1:15pm - 1:45pm EST)
Introduction to Therapeutic Oligonucleotide Conjugates II
- Disease Areas of interest
- Ligand opportunities
- Lipid, Antibody, GalNAc siRNA conjugates
- Lipid, Antibody, GalNac ASO conjugates
- Peptide ASO, SSO conjugates
- Antibody SSO conjugates
- Two choices in Oligonucleotide conjugate synthesis
(1:45pm - 2:15pm EST)
Oligonucleotide Conjugate Synthesis
- Solid phase synthesis of conjugates
- Solution phase synthesis of conjugates
(2:15pm - 2:30pm EST)
Q&A and Group Discussion
Day 2 - Wednesday, June 9
(12:00pm - 12:15pm EST)
Oligonucleotide Conjugate Synthesis
- Welcome words
- Short recapture of Day 1
(12:15pm - 1:00pm EST)
Oligonucleotide Conjugate Synthesis
- Case examples of Solid phase oligonucleotide conjugate synthesis
- Case examples of Solution phase oligonucleotide conjugate synthesis
(1:00pm - 1:15pm EST)
Break
(1:15pm - 1:45pm EST)
In depth Oligonucleotide Conjugate Synthesis
- Conjugation positions per specific oligonucleotide type
- Building block opportunities
(1:45pm - 2:15pm EST)
In depth Oligonucleotide Conjugate Synthesis
- Conjugation reactions
- Linker opportunities
(2:15pm - 2:30pm EST)
Q&A and Group Discussion
Day 3 - Thursday. June 10
(12:00pm - 12:30pm EST)
Biological Impact of Oligonucleotide Conjugates
- Short recapture of Day 1 and 2
- The biological impact of ligand conjugation
- Selecting your conjugation strategy
- To release or not to release your ligand
(12:30pm - 1:00pm EST)
Case Examples
- Case examples of biological impact as a result of conjugation control
(1:00pm - 1:15pm EST)
Break
(1:15pm - 1:45pm EST)
Biological Impact of Oligonucleotide Conjugates
- How to Setup Your Own Conjugation Chemistry
(1:45pm - 2:30pm EST)
Q&A and Group Discussion
October 26-28 Training Course Schedule
8:30am - 11:00am EST / 1:30pm - 4:00pm GMT / 2:30pm - 5:00pm CET / 9:30pm - 12:00am JST / 5:30am - 7:00am PCT
This course will also be available on-demand for anyone with a time conflict.
Day 1 - Tuesday, October 26
(8:30am - 9:00am EST)
Introduction to Speaker and Workshop
- Welcome words
- Speaker introduction
- Content of the Workshop
- What is a conjugate?
(9:00am - 9:30am EST)
Introduction to Therapeutic Oligonucleotide Conjugates I
- Different types of oligonucleotides and their mode of action.
- Why do we need Oligonucleotide conjugates?
- Do we always need Oligonucleotide conjugates?
- Clinical status of Oligonucleotide conjugates
(9:30am - 9:45am EST)
Break
(9:45am - 10:15am EST)
Introduction to Therapeutic Oligonucleotide Conjugates II
- Disease Areas of interest
- Ligand opportunities
- Lipid, Antibody, GalNAc siRNA conjugates
- Lipid, Antibody, GalNac ASO conjugates
- Peptide ASO, SSO conjugates
- Antibody SSO conjugates
- Two choices in Oligonucleotide conjugate synthesis
(10:15am - 10:45am EST)
Oligonucleotide Conjugate Synthesis
- Solid phase synthesis of conjugates
- Solution phase synthesis of conjugates
(10:45am - 11:00am EST)
Q&A and Group Discussion
Day 2 - Wednesday, October 27
(8:30am - 8:45am EST)
Oligonucleotide Conjugate Synthesis
- Welcome words
- Short recapture of Day 1
(8:45am - 9:30am EST)
Oligonucleotide Conjugate Synthesis
- Case examples of Solid phase oligonucleotide conjugate synthesis
- Case examples of Solution phase oligonucleotide conjugate synthesis
(9:30am - 9:45am EST)
Break
(9:45am - 10:15am EST)
In depth Oligonucleotide Conjugate Synthesis
- Conjugation positions per specific oligonucleotide type
- Building block opportunities
(10:15am - 10:45am EST)
In depth Oligonucleotide Conjugate Synthesis
- Conjugation reactions
- Linker opportunities
(10:45am - 11:00am EST)
Q&A and Group Discussion
Day 3 - Thursday, October 28
(8:30am - 9:00am EST)
Biological Impact of Oligonucleotide Conjugates
- Short recapture of Day 1 and 2
- The biological impact of ligand conjugation
- Selecting your conjugation strategy
- To release or not to release your ligand
(9:00am - 9:30am EST)
Case Examples
- Case examples of biological impact as a result of conjugation control
(9:30am - 9:45am EST)
Break
(9:45am - 10:15am EST)
Biological Impact of Oligonucleotide Conjugates
- How to Setup Your Own Conjugation Chemistry
(10:15am - 10:45am EST)
Q&A and Group Discussion
(10:45am - 11:00am EST)
Feedback and Closing Remarks