Track Title: Peptide Discovery to CMC
From Innovative Discovery to Scalable Manufacturing: The Complete Peptide Therapeutics Journey
Explore the full spectrum of peptide therapeutic development, from cutting-edge discovery platforms and novel design strategies to process optimization, regulatory compliance, and clinical translation. This comprehensive track bridges the gap between innovation and commercialization in the rapidly evolving peptide therapeutics landscape, featuring breakthrough technologies, real-world manufacturing case studies, and clinical insights across diverse therapeutic areas.
About This Track
This track provides an end-to-end perspective on peptide drug development, from discovery innovation and novel scaffolds to manufacturing excellence, regulatory insights, and clinical applications across oncology, metabolic disorders, and neurodegenerative diseases. Attendees will address critical challenges including scalability, sustainability, and CMC optimization while exploring breakthrough technologies that combine the specificity of biologics with the manufacturability of small molecules.
Novel Discovery Platforms
Explore KnotBody technology, bicyclic peptides, and high-throughput phenotypic screening
Manufacturing Excellence
Learn from real-world case studies including Tirzepatide and Dapiglutide scale-up challenges
Sustainable Chemistry
Discover green manufacturing approaches and environmentally conscious process design
Regulatory Intelligence
Gain insights from recent global Phase 3 peptide filings and regulatory strategies
Clinical Innovation
Hear about breakthrough applications in oncology, neurodegenerative diseases, and metabolic disorders
End-to-End Integration
Bridge discovery, development, and manufacturing with comprehensive CMC strategies
Industry Challenges We'll Address
Challenge 1: Discovery-to-Development Gap
Bridge the gap with integrated sessions covering discovery innovations and manufacturing realities
Challenge 2: Manufacturing Scalability
Learn from real-world case studies of successful scale-up, including blockbuster peptides
Challenge 3: Sustainability Pressures
Adopt green chemistry approaches without compromising quality
Challenge 4: Regulatory Complexity
Navigate global regulatory requirements with insights from recent Phase 3 filings
Challenge 5: Timeline Acceleration
Implement phase-appropriate development strategies to accelerate IND submission
Track Focus Areas
Innovations in Peptide Discovery
Discover breakthrough technologies and platforms that are expanding the therapeutic potential of peptides through novel scaffolds, screening approaches, and targeting strategies.
Featured Sessions:
- Innovations in Peptide Discovery
- KnotBody Technology: Presentation of Cys-rich "Knottin" Peptides within Antibody Scaffolds Unleashes the Power of Phage Display Technology
- Identification of Cyclic Peptides Synthetically Lethal to MTAP Deletion Cancer Cells through High Throughput Phenotypic Screening
- Targeting Fibrotic Tissue for Peptide-based Diagnostic and Therapeutic Applications
- Post-translational Modifications in Peptide Design and Activity
- Cyclisation of the Analgesic α-conotoxin Vc1.1 with a Non-natural Linker to Improve Biopharmaceutical Properties
- Peptides in Radioligand Therapy: Precision Targeting in Oncology
Peptide Process Development and Manufacturing
Navigate the complexities of peptide manufacturing from preclinical to commercial scale with insights into process optimization, timeline acceleration, and innovative synthesis approaches.
Sessions:
- Peptide Process Development and Manufacturing
- Case Studies of Pre-clinical Development and IND Acceleration for Peptides
- Accelerate Timeline to Start Phase I: Phase Appropriate Development and Integrated Drug Product Supply
- A Mild and Sustainable Platform for Disulfide Bond Formation in Peptide Manufacturing Using Dehydroascorbic Acid
- Dapiglutide: From Lab to Large Scale Manufacture through Innovative Peptide Process Development
- Made to Scale: What Tirzepatide's Manufacturing Challenge Teaches Us About Innovation Under Pressure
Innovations in Peptide CMC
Explore cutting-edge CMC approaches, analytical methods, sustainability initiatives, and regulatory insights for successful peptide therapeutic development.
Sessions:
- Innovations in Peptide CMC
- High-throughput Synthesis and Screening of > 80,000 Peptidic Compounds with Covalent Warheads
- Systematic Route Design for Fragment-Based Peptide Synthesis: Enabling Liquid-Phase Transition
- Identity Testing of Synthetic Peptides: From Multi-Method Evaluation to a Compliant Two-Test Scheme
- Sustainability in Peptide Manufacturing
- MCSGP Process Control and Characterization Strategy
- Regulatory Insights from Recent Global Phase 3 Peptide Filings
Peptide Preclinical and Clinical
Gain insights into the clinical translation of peptide therapeutics across diverse therapeutic areas, from antimicrobial applications to oncology and neurodegenerative diseases.
Sessions:
- Peptide Preclinical and Clinical
- Voxvoganan - A First in Class Mimetic of Antimicrobial Peptides
- Bicyclic Peptide Technology: Pioneering Next-Generation Precision-Guided Therapeutics
- Targeting Neurodegenerative Diseases with Priavoid's Peptide Drug Development Platform
- Oral GLP-1 Clinical Program or Amylin Phase 2 Program Update
- Next Generation Oncolytic Peptides – Drivers of Immunogenic Cell Death for Host Immune Activation
Who Will Benefit from This Track?
- Peptide medicinal chemists
- Discovery scientists
- Process development engineers
- CMC and analytical professionals
- Regulatory affairs specialists
- Formulation scientists
- Quality control managers
- Clinical researchers
- Pharmaceutical and biotech executives
- CDMO representatives
- Academic researchers transitioning to industry