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TIDES USA: Oligonucleotide & Peptide Therapeutics


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May 14-17, 2024 | In-Person + Digital
Boston, MA, USAHynes Convention Center

Claus Rentel, PhD
Vice President, Analytical Development/QC at Ionis Pharmaceuticals, Inc.


Dr. Rentel is currently Executive Director, Analytical Development and Quality Control at Ionis Pharmaceuticals, Inc., Carlsbad, California. Prior to joining Ionis in 2001 he worked in Quality Control and Special Analytics at CarboGen Laboratories AG, Aarau, Switzerland.

He received his Ph.D. (summa cum laude) from the University of Tuebingen, Germany.

Dr. Rentel has 20 years of experience in Quality Control and analytical method development and validation. He is an expert in mass spectrometric techniques, and has extensive expertise in the development of oligonucleotide therapeutics in regards to specifications, testing of starting materials, reagents, drug substance intermediates, drug substances, drug products and toxicological samples, as well as installation and validation of IT Quality Systems. He has been responsible for the CMC drug substance section of IND filings for more than 40 oligonucleotides, and participated in the NDA filings for mipomersen, nusinersen, volanesorsen and inotersen.

Claus Rentel, PhD's Network

Agenda Sessions

  • Nonstereoselective Synthesis: Process, Control and Regulatory Considerations

  • Chairman’s Remarks: Analytics for Oligonucleotide Modalities

  • Considerations for Method Development of siRNA Duplexes