Yingnan Zhang

Senior Principal Scientific Manager at Genentech

Speaker

Yingnan Zhang, Ph.D. in Biochemistry, is a Senior Principal Scientific Manager at Genentech. She got her Ph.D in the field of enzymology and glycobiology from University of Miami, FL mentored by Dr. Keith Brew. She joined Genentech as a postdoc mentored by Dr. Sachdev Sidhu. She has been involved in many projects with phage display as technology platform during her career at Genentech. These include: generating specificity map for PDZ domain family; discovery of Dvl antagonist for Wnt signaling pathway regulation, identification of specific peptide inhibitors to proteases, e.g. BACE1 and caspase 6; engineering ubiquitin to specific inhibitor of DUB by exploring conformation diversity of ubiquitin; identification of peptide antagonists against PCSK9, and development of libraries with Disulfide Constrained Peptide (DCP) scaffolds. She has led the diversity display lab at Department of Early Discovery Biochemistry in Genentech for over fifteen years.