David Butler, PhD

Principal Investigator at Neural Stem Cell Institute

Speaker

In 2001 I started graduate school at West Virginia University School of Medicine and joined the lab of Dr. Steve Alway, where I studied the age-related changes in muscle structure and function that occur during sarcopenia in myogenic stem cells. As a postdoctoral research fellow in Dr. Anne Messer’s lab at the Wadsworth Center, my research shifted toward developing immunotherapeutics for the treatment of neurodegenerative disorders due to misfolded proteins in Parkinson’s disease and Huntington’s disease. In 2014, I joined the Neural Stem Cell Institute as a principal investigator, where I have been generating and characterizing series of isogenic induced pluripotent stem cell lines with familial tau mutations. These ‘Disease in a Dish’ models of tauopathies are currently being used for drug screening as well as anti-tau intrabody development.