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Antibody Engineering & Therapeutics Series

Pierre Bruhns, PhD
Deputy Director at Institut Pasteur

Profile

Pierre Bruhns received his PhD in Immunology at the University of Paris, France in 2001. He performed his post-doc (2001-2004) under Jeffrey Ravetch at the Rockefeller University, NY, USA, studying the mechanisms of action of IVIG, and identifying mouse FcgRIV. Since 2004, he leads research on mouse and human Fc receptor biology at the Institut Pasteur (Paris, France). Since 2012, he directs the research unit of Antibodies in Therapy & Pathology focusing on mechanism of severe allergic reactions (anaphylaxis), autoimmunity and Ab-mediated cancer immunotherapy. He created in collaboration with Regeneron Pharmaceuticals a series of knock-in mice expressing human IgG and their receptors (FcgR, FcRn, C1q). Since 2014 his lab uses droplet microfluidics to analyze antibody-secreting cells for their phenotype and their antibody repertoire in physiology and disease. He is a recipient of an ERC consolidator grant and of major national grants, and inventor on several patents.