Your molecule is unique. Your CHO host should be too.

Demeetra engineers CHO host cell lines to fit the molecule, not the other way around. The CleanCut GS platform reaches 18 g/L for mAbs and 5 g/L for bsAbs, all stably integrated with our license free Harbor-IN transposase. From that base we precisely edit hosts to overcome specific manufacturing challenges. ADCC+ produces afucosylated antibodies with higher potency. Low-HCP removes the lipases that degrade polysorbate. Resilient delays apoptosis and extends the productive window. Xeno removes non-human glycan epitopes. Amplify expands secretory capacity.

Every edit is made with Cas-CLOVER, our dimerization-dependent nuclease. It multiplexes efficiently and comes with clean FTO. No additional editing licenses required.

We license the platforms and we run cell line development services. Visit the booth to talk through which host fits your molecule.