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Delivered as a Hybrid Event
May 9-12, 2022Hynes Convention Center, Bostonkeyboard_arrow_right
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Main Conference - Day 2
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Main Conference - Day 2
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Streams
6:00am - 7:00am60 mins
Morning Fun Run
7:30am - 7:45am15 mins
Registration
7:45am - 8:15am30 mins
Breakfast Spotlight Presentations 2
ROOM 204AB: Regulatory Experience Sharing: Excipients for use in Lipid Nanoparticles
8:15am - 8:20am5 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Chairman’s Remarks
8:20am - 8:45am25 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Analytical Method Development for Critical Impurities in Phosphoramidites
8:25am - 8:30am5 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Emerging Oligonucleotide Drug Discovery
ROOM 205A: Chairman’s Remarks
- P. Peter Ghoroghchian, Ph.D. - Co-Founder, President and CEO, Ceptur Therapeutics
8:25am - 8:30am5 mins
Peptides TRACK: Peptides for COVID-19 Therapy
ROOM 205B: Chairman’s Remarks
- Trishul Shah, M.S. - Director Business Development, PolyPeptide Laboratories Inc.
8:25am - 8:30am5 mins
mRNA and Genome Editing TRACK: mRNA Discovery, Delivery and Translation to the Clinic
ROOM 205C: Chairman’s Remarks
8:30am - 9:00am30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Emerging Oligonucleotide Drug Discovery
ROOM 205A: Targeting ANGPTL4 in the Liver with ASO – A Novel Treatment for Cardiometabolic Disease
8:30am - 9:00am30 mins
Peptides TRACK: Peptides for COVID-19 Therapy
ROOM 205B: Treatment with Vasoactive Intestinal Peptide (aviptadil) is Life-saving in Patients with Critical COVID-19
8:30am - 9:00am30 mins
mRNA and Genome Editing TRACK: mRNA Discovery, Delivery and Translation to the Clinic
ROOM 205C: Programming mRNA for Cancer Immunotherapy
8:45am - 9:10am25 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Automated Online UPLC and Data Processing for Oligonucleotide Synthesis and Purification Monitoring
9:00am - 9:30am30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Emerging Oligonucleotide Drug Discovery
ROOM 205A: U1 Adaptors Bioconjugates for Targeted Gene Silencing in Extrahepatic Tissues
- P. Peter Ghoroghchian, Ph.D. - Co-Founder, President and CEO, Ceptur Therapeutics
9:00am - 9:30am30 mins
Peptides TRACK: Peptides for COVID-19 Therapy
ROOM 205B: Developing a Highly Conserved, Non-human-like, and Cross-reactive SARS-CoV-2 Peptide-based COVID-19 Vaccine
9:00am - 9:30am30 mins
mRNA and Genome Editing TRACK: mRNA Discovery, Delivery and Translation to the Clinic
ROOM 205C: A Novel Vaccine Approach Using Messenger RNA‐Lipid Nanoparticles: Preclinical and Clinical Perspective
- Ying Tam, Ph.D. - Chief Scientific Officer, Acuitas Therapeutics
9:10am - 9:35am25 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Control of GalNAc siRNA Conjugates
9:30am - 10:00am30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Emerging Oligonucleotide Drug Discovery
ROOM 205A: A Novel, RNA-based Anti-viral Approach to Limit BK Virus Propagation in Immunocompromised Patients
9:30am - 10:00am30 mins
Peptides TRACK: Peptides for COVID-19 Therapy
ROOM 205B: When the Process Doesn't Fit - 8 Weeks to Build a Purification Suite to Support A Critical Covid-19 Vaccine Adjuvant
9:30am - 10:00am30 mins
mRNA and Genome Editing TRACK: mRNA Discovery, Delivery and Translation to the Clinic
ROOM 205C: Preclinical Immunogenicity Characterization of ARCT-021 SARS-CoV-2 Vaccine
9:35am - 10:00am25 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Suppressing the Inherent Reactivity of Labile Moieties during Purity and Identity Characterization
10:00am - 10:45am45 mins
Networking Refreshment Break in Poster and Exhibit Hall
10:45am - 11:15am30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Analytical Method Development of Complementary Related Organic Impurity Methods for Oligonucleotides
10:45am - 11:15am30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Emerging Oligonucleotide Drug Discovery
ROOM 205A: Platform Optimization to Enable Therapeutic Development of ADAR-mediated RNA editing
10:45am - 11:15am30 mins
Peptides TRACK: Peptide Discovery and Development
ROOM 205B: Solid-Phase Peptide Synthesis Using a Four-Dimensional Protecting Group Scheme
10:45am - 11:15am30 mins
mRNA and Genome Editing TRACK: mRNA Discovery, Delivery and Translation to the Clinic
ROOM 205C: Subcutaneous Administration of mRNA LNPs to Achieve Systemic Exposures of Protein
11:15am - 11:45am30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Identification and Quantitation of Thermal Degradation Products of Antisense Oligonucleotides (ASOs) Enables Understanding of Degradation Mechanism
11:15am - 11:45am30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Emerging Oligonucleotide Drug Discovery
ROOM 205A: Development of an Antisense Oligonucleotide, STK-001, for Dravet Syndrome
11:15am - 11:45am30 mins
Peptides TRACK: Peptide Discovery and Development
ROOM 205B: Discovery and Optimization of Long-acting, Unimolecular Peptide Triple Agonists of the GLP-1, GIP, and Glucagon Receptors
11:15am - 11:45am30 mins
mRNA and Genome Editing TRACK: mRNA Discovery, Delivery and Translation to the Clinic
ROOM 205C: A Platform Approach for mRNA Vaccine Development
11:45am - 12:15pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Analytics of Oligonucleotides
ROOM 204AB: Advancing the Pharmaceutical Science of Lipid Delivery Systems and their Translation to the Clinic
11:45am - 12:15pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Emerging Oligonucleotide Drug Discovery
Please Choose Another Track
11:45am - 12:15pm30 mins
Peptides TRACK: Peptide Discovery and Development
ROOM 205B: Oral Delivery of PTH 1-34 in the Treatment of Hypoparathyroidism and Osteoporosis
11:45am - 12:15pm30 mins
mRNA and Genome Editing TRACK: mRNA Discovery, Delivery and Translation to the Clinic
ROOM 205C: CMC Regulatory Strategies for mRNA Vaccines
12:15pm - 12:20pm5 mins
Transition to Spotlight Presentation Rooms
Spotlight Presentations
12:20pm - 12:50pm30 mins
Spotlight Presentation 1
ROOM 204AB: An Introduction to OCELOT™ System Control
- Stefan Hyde - Automation Manager, Asahi Kasei Bioprocess America
12:20pm - 12:50pm30 mins
Spotlight Presentation 2
ROOM 205A: Development, Optimization and Scale up of Therapeutic Peptides: Approaches to Solid Phase Synthesis
12:20pm - 12:50pm30 mins
Spotlight Presentation 3
ROOM 205B: Leveraging High Resolution Mass Spectrometry for the Analysis of Process and Product Related Impurities for Synthetic Oligonucleotides
12:20pm - 12:50pm30 mins
Spotlight Presentation 4
ROOM 205C: Plan Now or Fail Later: Why Raw Materials Matter
- Darwin Asa, Ph.D - Global Market Development Manager - Nucleic Acid Therapeutics, Thermo Fisher Scientific
12:50pm - 1:55pm65 mins
Networking Luncheon in Poster and Exhibit Hall
1:55pm - 2:00pm5 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
ROOM 204AB: Chairman’s Remarks
- Firoz Antia, PhD - Executive Director, Head of Oligonucleotide Development, Biogen
1:55pm - 2:00pm5 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
ROOM 205A: Chairman’s Remarks
- Punit Seth, PhD - Vice President, Medicinal Chemistry, Ionis Pharmaceuticals
1:55pm - 2:00pm5 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
ROOM 205B: Chairman’s Remarks
- Jesse Dong, Ph.D. - Vice President, Peptide Chemistry, BioNTech
1:55pm - 2:00pm5 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
ROOM 205C: Chairman’s Remarks
2:00pm - 2:30pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
ROOM 204AB: Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
- Ben Andrews, Ph.D. - Scientific Investigator, GlaxoSmithKline
2:00pm - 2:30pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
ROOM 205A: Old Dogs and New Puppies of Chemical Modifications for RNA Therapeutics
- Muthiah (Mano) Manoharan, PhD - Senior Vice President of Drug Discovery, Alnylam Pharmaceuticals
2:00pm - 2:30pm30 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
ROOM 205B: Tumor-targeted Radionuclides Using De Novo Macrocyclic Peptide-mimetics
2:00pm - 2:30pm30 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
ROOM 205C: Development of Broadly Protective Influenza Vaccines Using Nucleoside-modified mRNA
- Norbert Pardi, PhD - Research Assistant Professor of Medicine, University of Pennsylvania
2:30pm - 3:00pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
ROOM 204AB: Small Materials – Drivers (or Disasters) for Oligonucleotide Sustainability
2:30pm - 3:00pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
ROOM 205A: Chemical Modification of Guide RNA in Genome Editing
2:30pm - 3:00pm30 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
ROOM 205B: Development of Targeted Alpha Therapeutics for the Treatment of Solid Tumors
2:30pm - 3:00pm30 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
ROOM 205C: Fully Protective Anti-malaria Immunity by a Self-amplifying RNA Vaccine
3:00pm - 3:30pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
ROOM 204AB: Delivering the Promise of Nucleic Acid Medicines: The Challenge of Scale Cost and Sustainability
3:00pm - 3:30pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
ROOM 205A: Oligonucleotide Backbone Engineering for Enhancing Metabolic Stability, Potency, and Selectivity of siRNAs
3:00pm - 3:30pm30 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
ROOM 205B: Targeted Delivery of Radionuclides
3:00pm - 3:30pm30 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
ROOM 205C: mRNA Vaccines for Malaria
3:30pm - 4:00pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
Networking Refreshment Break in Poster and Exhibit Hall
3:30pm - 4:00pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
Networking Refreshment Break in Poster and Exhibit Hall
3:30pm - 4:00pm30 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
Networking Refreshment Break in Poster and Exhibit Hall
3:30pm - 4:00pm30 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
Networking Refreshment Break in Poster and Exhibit Hall
4:00pm - 4:30pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
ROOM 204AB: Development of a Scalable Synthesis Process for Oligonucleotides
4:00pm - 4:30pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
ROOM 205A: Redefining the Chemical Space for Antisense Therapeutics
- Punit Seth, PhD - Vice President, Medicinal Chemistry, Ionis Pharmaceuticals
4:00pm - 4:30pm30 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
ROOM 205B: New Peptide Receptor Radionuclide Therapy Theranostic Indications
4:00pm - 4:30pm30 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
ROOM 205C: RNActive® - CureVac’s mRNA Vaccines Against Different Pathogens
4:30pm - 5:00pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
ROOM 204AB: In Defense of Solid-Phase Oligonucleotide Synthesis (Costs/Strategic/Technical)
4:30pm - 5:00pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
ROOM 205A: Sequence-specific Recognition of Double-stranded RNA by Cationic Nucleobase and Backbone-modified Peptide Nucleic Acids
4:30pm - 5:00pm30 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
ROOM 205B: Journey Beyond the Margin: Development of Imaging System to Assist Tumor Resections
4:30pm - 5:00pm30 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
ROOM 205C: Optimization of LNPs for Improved mRNA Vaccines
5:00pm - 5:30pm30 mins
Oligonucleotide CMC and Targeted Delivery TRACK: Sustainable Manufacturing of Oligos
ROOM 204AB: How Honeywell is Meeting the Need For Sustainable and Cost-Effective Solvent and Reagent Technology
5:00pm - 5:30pm30 mins
Oligonucleotide Discovery to Clinic and CMC TRACK: Nucleic Acid Chemical Modifications
ROOM 205A: Exploring New Oligonucleotide Backbone Chemistries and Their Deployment to Improve the Properties of Stereopure Oligonucleotides
5:00pm - 5:30pm30 mins
Peptides TRACK: Targeted Radioligand Therapies and Tumor Imaging with Peptides and Other Molecules
Close of Track
5:00pm - 5:30pm30 mins
mRNA and Genome Editing TRACK: mRNA Vaccines for Non-COVID-19 Indications
Close of Track
5:30pm - 8:00pm150 mins
Party on Lawn D
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