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BIO-Europe Spring

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THE SPRINGTIME PARTNERING EVENT
March 18–20, 2024 | Barcelona, SpainMarch 26–27, 2024 | Digital Partnering

Exazyme GmbH

Profile

Exazyme’s mission is to make designing chemistry and biology as easy as using an app – facilitating the ideas that shorten the wait to solve the world’s most pressing problems: from CO2 to cancer. With Exazyme’s app, biotech innovators can discover the best possible protein for their goals while drastically reducing the number of experiments required. They may need 100 times fewer experiments than with standard methods – and achieve superior results. Exazyme is used by protein engineers in the pharmaceutical, industrial biotechnology and green biotechnology industries. The app helps to design better drugs and therapies, chemicals and food, and improve plant properties for hardiness, productivity, and CO2 absorption. Breakthroughs in collaborations, such as with Max Planck, demonstrate our success. In a recent project, we engineered a biocatalyst for rapid CO2 fixation, outperforming existing methods by far. Exazyme's AI streamlined the engineering of the key carboxylase in synthetic CO2 fixation and reduced the screening effort. By doing so, we provide two novel enzymes with 2-fold improved carboxylation rate and 60 % reduced energy demand that are able to overcome the thermodynamic limitations of the tartronyl-CoA (TaCo) pathway, a synthetic photorespiration bypass that was recently designed to improve photosynthetic CO2 fixation. (more details can be read here: https://pubs.acs.org/doi/10.1021/acssynbio.3c00403)