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Main Conference - Day 2 (May 13)
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Main Conference - Day 2 (May 13)
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mRNA & Genome Editing: Technology & Applications
8:25am - 8:30am
Chairman’s Remarks
- Cecilia Fernández, Ph.D. - Entrepreneur in Residence, Mass General Brigham Ventures
8:30am - 9:00am
Transformative LDL Cholesterol Lowering In Vivo CRISPR Gene Editing Approach for Hyperlipidemia and Atherosclerotic Cardiovascular Disease
- Linda Burkly - Executive Vice President & Chief Scientific Office, Editas Medicine
9:00am - 9:30am
Toward In Vivo Genetic Medicines with Site-specific Integration of Therapeutically Relevant Genes Via an RNA-only Platform
- Ari Friedland - Vice President of Research, Typewriter Therapeutics
9:30am - 10:00am
Development of Bespoke Genome Editing Technologies to Treat Disease
- Ben Kleinstiver, PhD - Associate Professor, Massachusetts General Hospital & Harvard Medical School
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mRNA & Genome Editing: Technology & Applications
10:45am - 11:15am
Applying Machine Learning to Identify Differentiated Target Mechanisms and Design Next-Generation Oligonucleotide Therapeutics
- Greg Hoffman, PhD - Chief Scientific Officer, Deep Genomics
11:15am - 11:45am
Delivery of Gene Writers to Hematopoetic Stem Cells towards an In Vivo Therapy for Sickle Cell Disease
- Jane Wang, PhD - VP and Head of Delivery and Process Devlopment, Tessera Therapeutics
11:45am - 12:15pm
Late Breaking Presentation
12:15pm - 12:20pm
Transition to Spotlight Presentation Rooms
Concurrent Tracks
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mRNA & Genome Editing: Technology & Applications
1:55pm - 2:00pm
Co-Chairs' Remarks
- Seth Alexander, PhD - Director of RNA Technologies, Prime Medicine
- Bradley Pentelute, PhD - Professor, Chemistry, Massachusetts Institute of Technology
2:00pm - 2:30pm
Efficient Modification Chemistry for RNA Stabilization and Control
- Eric Kool, Ph.D - Professor of Chemistry, Stanford University
2:30pm - 3:00pm
Beyond Codons: The Structural and Regulatory Logic Governing mRNA Translation
- Devan Shah - Founder & Chief Executive Officer, RNAV8 Bio
3:00pm - 3:30pm
Analytical Platform Technologies for mRNA-based Therapeutics and Vaccines
- Andreas Kuhn, PhD - Senior Vice President RNA Biochemistry & CMC Development, BioNTech SE
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mRNA & Genome Editing: Technology & Applications
4:15pm - 4:45pm
Self-replicating RNA (srRNA) Vaccines Using Unmodified Bases Show An Expanded Clinical Therapeutic Index and Sustained Immune Responses
- Andrew Geall, PhD - Co-founder and Chief Development Officer, Replicate Bioscience
4:45pm - 5:15pm
Process and Technology Innovation for RNA Therapeutics
- Telmo Graça, PhD - Head of mRNA Process Development, Lonza
5:15pm - 5:45pm
Enabling Next-Generation mRNA Therapeutics Through a Cell-Based mRNA Design and Manufacturing Platform
- Marian Kupculak, PhD - Co-Founder and Chief Science Officer, Sensible Biotechnologies
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