Madelon Maurice

Full Professor at UMC Utrecht

Speaker

Madelon Maurice is appointed Full Professor at the UMC Utrecht and member of the national Oncode Institute for cancer research. She is internationally recognized for contributing key mechanistic insights into how stem cell-niche communication controls tissue renewal, and how cancer mutations impact on these processes. Her academic group employs a multiscale approach that allows for the investigation of molecular processes in complex tissues using organoid-based model systems (https://madelonmauricelab.nl/). A longstanding interest is to understand ubiquitin-mediated regulation of key signaling pathways, highlighted by i) the discovery that the membrane-bound E3 ligase RNF43 controls Wnt receptor turnover in stem cells, and ii) the invention of SureTACs technology for targeted membrane protein degradation. The innovative nature of her work was recognized with various prestigious grants (e.g. ERC-St, NWO-VICI, ZonMW-TOP, national Gravitation grant IMAGINE!). She is a regular invited speaker and organizer of international meetings (e.g. GRC, EMBO). Madelon is co-founder, shareholder, and chair of the Scientific Advisory Board (SAB) of the biotech company Laigo Bio that aims to develop SureTACs technology for clinical applications.