Agenda - Tuesday March 10 | BioProcess International US West

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Recovery & Purification

8:55am - 9:00am

Chairperson's Opening Remarks: Recovery & Purification

9:00am - 9:30am

Designing Robust DSP Trains for High-Titer Bispecific Antibodies

Renee Chen - Senior Scientist, AbbVie

9:30am - 10:00am

Utilizing Continuous, Connected Chromatography to Alleviate Downstream Bottlenecks Caused by Upstream Process Intensification

Running multiple cycles on smaller chromatography columns in dual column mode, as well as connecting multiple unit operations together in continuous fashion is a strategy to enable processing of the additional mass entering the downstream process from intensified fed batch bioreactors.
Continuous multi-cycle operation ensures that the processing time meets or even exceeds that of standard batch methods, enabling facilities to meet their required run rates without compromising purity or yield.
The reduction in chromatography resin volume and buffer usage enables a reduced facility footprint and lower cost of goods of manufacturing, while also improving sustainability initiatives

Chris Afdahl - Associate Director, AstraZeneca

10:00am - 10:30am

Efforts to Accelerate Pipeline Process Development for Downstream Phase 1-3

Dimple Chavan - Senior Scientist, AstraZeneca

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Recovery & Purification

11:15am - 11:45am

Continuous Downstream Processing of mAbs via Precipitation

Continuous downstream processing based on capture via target precipitation and polish via flowthrough chromatography offers a low cost-of-goods, low process mass index, and low complexity pathway to monoclonal antibody manufacture.
Yield, purity, and throughput metrics for the precipitation-based process compare favorably to those for platform Protein A downstream processes.
Capture via precipitation is broadly applicable to monoclonal antibodies and antibody-like therapeutics.
The process development workflow in terms of selection of precipitant conditions and polishing resins is straightforward.

Yuncan (Olivia) Zhu - Postdoctoral Research Fellow, Rensselaer Polytechnic Institute

11:45am - 12:15pm

10-fold Improvement in Depth Filter Capacity through Cycling Operation during Integrated Dynamic Bioprocessing (IDB) purification

David Scherr - Senior Scientist, AstraZeneca

12:15pm - 12:45pm

Sartorious

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Recovery & Purification

2:00pm - 2:30pm

Enabling Subcutaneous Formulations: A High-Throughput Computational (DeepViscosity) and Experimental (SAXS) Framework for Assessing High-Concentration Monoclonal Antibody Viscosity

Lateefat Kayejaye - Graduate Research Assistant, Stevens Institute of Technology

2:30pm - 3:00pm

Challenges and Solutions to Manufacturing Low Viscosity, Ultra-High Concentration IgG1 Drug Products: From Late Downstream Process to Final Fill-Finish Processing

Vaibhav Deokar - Principal Scientist, Lupin Limited (Biotech Division)

3:00pm - 3:30pm

Thermo

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Recovery & Purification

4:15pm - 4:45pm

Assessment of Mass Spectrometry Platforms and Software for Host Cell Protein Analysis

Jing Wang - Senior Scientist, Regeneron

4:45pm - 5:15pm

Case Studies on Utilizing Magnetic Resin with Self-Removing Tags to Improve Process Development

David Wood - Professor of Chemical and Biomolecular Engineering, Ohio State University

5:15pm - 5:45pm

Panel Discussion - Infusing AI into Downstream Processing

Stefano Menegatti - Professor, Chemical and Biomolecular Engineering, NC State University, North Carolina State University

Tuesday March 10Tuesday, 10 March 2026 - PT (Pacific Time, GMT-08:00)

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