The talk will focus on our pre-clinical and clinical experience with CD27 monoclonal antibodies and consider how their therapeutic activity might be improved.

A recent clinical trial involving MOv18 IgE, provided tantalising evidence of IgE’s potential for the treatment of cancer. Epsilogen is conducting a phase Ib trial in which translational data will be collated to further understand mechanisms associated with IgE therapy. In addition, Epsilogen has established a pipeline of anti-tumoral IgEs and two novel platforms: bispecific IgE and a hybrid antibody which combines the effector functions of IgE and IgG.

The FORCE™ platform was designed to enhance delivery of oligonucleotide to muscle for the treatment of neuromuscular disorders by conjugating them to an antigen-binding fragment (Fab) that is selective for the human transferrin receptor 1 (TfR1). In this presentation, we introduce the properties and modularity of the FORCE platform and provide evidence of translation between pre-clinical models and clinical proof of concept in myotonic dystrophy type 1 (DM1) with DYNE-101.

We show unique mechanisms of flexible homodimerization crucial for the inhibitory function of checkpoint receptor PD-1 and LAG-3, and identified a novel cell surface receptor potently modulating myeloid-associated Type-I IFN responses. These efforts laid the foundation for developing novel immunotherapies for cancer and autoimmune diseases.