Eriko Matsuda

Head of Lead Identification, Discovery Biologics at Chugai Pharmaceutical Co. Ltd.

Speaker

We previously developed SMART-Ig® technology to efficiently remove soluble antigens from the blood. This time, we aimed for more efficient antigen removal by creating pH-dependent biparatopic antibodies that bind to different epitopes of a soluble monomeric antigen in a pH-dependent manner. These antibodies accelerated cellular uptake by forming larger immune complexes, successfully removing soluble antigens from the blood more efficiently.