Dr. Michael Zager, PhD

Associate Research Fellow, Pharmacokinetics, Dynamics, & Metabolism at Pfizer

Speaker

Mike started his career in pharmaceuticals joining the preclinical modeling and simulation group at Pfizer in 2005. He has worked in several therapeutic areas, mostly focusing on a variety of topics in oncology. Mike was fortunate to participate in the conception and rise of the quantitative systems pharmacology (QSP) modeling philosophy during his career. Most recently, he has focused on using modeling and simulation to aid in the design of biologics-based modalities to treat cancer, including antibody-drug conjugates (ADCs) and immune cell engagers. Currently, Mike leads preclinical modeling and simulation efforts for ADCs at Pfizer and works with a global team of experts aimed at developing state-of-the-science modeling methods to tackle challenges in biologics drug discovery, including prediction of human pharmacokinetics, translation of preclinical pharmacokinetic-pharmacodynamic relationships to human, and distribution of monoclonal antibodies in tumors.