Otsuka Pharmaceutical Europe Ltd. (OPEL) is the European operation of global healthcare company Otsuka Pharmaceutical Co., Ltd., which was founded in Japan in 1921. Otsuka expanded its pharmaceutical business into Europe in 1974 with the opening of a representative European office in Italy and subsequently invested in Laboratorios Miquel S.A. of Spain. Laboratorios Miquel S.A. became our first operating company in Europe. Otsuka Pharmaceutical Europe Ltd. (OPEL) was established in the U.K. in 1997 as Otsuka’s European regional office, and across Europe we now employ over 500 people. We focus on some of Europe’s most serious health challenges in neuroscience, nephrology, haemato-oncology and endocrinology. We are also exploring how digital health technology may provide holistic health solutions for patients, carers and healthcare professionals. Core functions of sales and marketing, medical and access are present in our affiliate offices across Europe and are supported by OPEL. For other European countries, Otsuka products are managed through a number of partnerships and distributors, ensuring wide European coverage.