Main Conference Day 2 - PT (Pacific Time, GMT-08:00)
In this talk, we present the CHO Edge System, which integrates a glutamine synthetase (GS) -CRISPR knockout CHO host, a hyperactive transposase, libraries of characterized genetic elements to control cellular functions, and computational tools for rational vector design and multi-omics analysis. We present case studies highlighting the impact of these tools to optimize expression for both standard monoclonal and bispecific antibodies.
- Imroz Ghangas - Vice President of Commercial Sales, Asimov
TfR1 shuttles show promise for CNS therapeutics, but toxicities remain limiting. We introduce a high-throughput in vivo screening method to engineer novel brain shuttles. Powered by AI and Manifold's protein barcoding technology, our approach reveals novel shuttle targets and shuttles with enhanced tissue selectivity, reduced toxicity profiles, and optimized biodistribution.
- Karen Duffy, PhD - Principal Scientist, Manifold Bio